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The effects of Glycyrrhizae uralenis and its major bioactive components on pharmacokinetics of daphnetin in Cortex daphnes in rats |
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| Authors: | Wen Zhang Liu-qing Di Jun-Song Li Jin-jun Shan An Kang Shuai Qian Le-tian Chen |
| Institution: | 1. School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, PR China;2. Jiangsu Engineering Research Center for Efficient Delivery System of TCM, PR China;3. Nanjing Engineering Research Center for Industrialization of Chinese Medicine Pellets, PR China;4. First Medicine School, Nanjing University of Chinese Medicine, Nanjing 210046, PR China;5. School of Pharmacy, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, PR China |
| Abstract: | |
| Keywords: | CD Cortex daphnes GU Glycyrrhizae uralenis CD&ndash GU combination of CD and GU TCHM traditional Chinese herbal medicine CYP cytochrome UGT UDP-glucuronosyltransferase Cmax peak plasma concentration Tmax time to Cmax AUC0&ndash t area under the curve from 0 to time AUC0&ndash &infin area under the curve from 0 to infinity T1/2z terminal elimination half-life MRT mean residence time |
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