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Chemical variability along the value chains of turmeric (Curcuma longa): A comparison of nuclear magnetic resonance spectroscopy and high performance thin layer chromatography
Authors:Anthony Booker  Debora Frommenwiler  Deborah Johnston  Chinenye Umealajekwu  Eike Reich  Michael Heinrich
Institution:1. Centre for Pharmacognosy and Phytotherapy, UCL School of Pharmacy, University of London, UK;2. CAMAG AG, 4132 Muttenz, Switzerland;3. School of Oriental and African Studies, University of London, Thornhaugh Street, Russell Square, London, UK;4. Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia
Abstract:

Ethnopharmacological relevance

Herbal medicine value chains have generally been overlooked compared with food commodities. Not surprisingly, revenue generation tends to be weighted towards the end of the chain and consequently the farmers and producers are the lowest paid beneficiaries. Value chains have an impact both on the livelihood of producers and on the composition and quality of products commonly sold locally and globally and consequently on the consumers. In order to understand the impact of value chains on the composition of products, we studied the production conditions for turmeric (Curcuma longa) and the metabolomic composition of products derived from it. We aimed at integrating these two components in order to gain a better understanding of the effect of different value chains on the livelihoods of some producers.

Materials and methods

This interdisciplinary project uses a mixed methods approach. Case studies were undertaken on two separate sites in India. Data was initially gathered on herbal medicine value chains by means of semi-structured interviews and non-participant observations. Samples were collected from locations in India, Europe and the USA and analysed using 1H NMR spectroscopy coupled with multivariate analysis software and with high performance thin layer chromatography (HPTLC).

Results

We investigate medicinal plant value chains and interpret the impact different value chains have on some aspects of the livelihoods of producers in India and, for the first time, analytically assess the chemical variability and quality implications that different value chains may have on the products available to end users in Europe. There are benefits to farmers that belonged to an integrated chain and the resulting products were subject to a higher standard of processing and storage.By using analytical methods, including HPTLC and 1H NMR spectroscopy, it has been possible to correlate some variations in product composition for selected producers and identify strengths and weaknesses of some types of value chains. The two analytical techniques provide different and complementary data and together they can be used to effectively differentiate between a wide variety of crude drug powders and herbal medicinal products.

Conclusions

This project demonstrates that there is a need to study the links between producers and consumers of commodities produced in so-called ‘provider countries’ and that metabolomics offer a novel way of assessing the chemical variability along a value chain. This also has implications for understanding the impact this has on the livelihood of those along the value chain.
Keywords:AE  aqueous extract  C  cosmetic  DMSO  dimethylsulphoxide  Drh  dried rhizome  EE  ethanolic extract  F  food  FRh  fresh rhizome  GAP  good agricultural practice  HMP  herbal medicinal product  HPMC  hydroxypropyl methylcellulose  HPTLC  high performance thin layer chromatography  LEDC  less economically developed country  LCIRAH  Leverhulme Centre for Integrative Research on Agriculture and Health  M  medicinal  MEDC  more economically developed countries  MHRA  Medicines and Healthcare Products Regulatory Agency  NMR  nuclear magnetic resonance  PCA  principal component analysis  PRC  Peoples Republic of China  PW  Powdered drug  Rf  retention factor  SCF  super critical fluid extract  TCM  traditional Chinese medicine  THMPD  traditional herbal medicinal products directive  VIVC  vertically integrated value chain  WHO  World Health Organisation  WRT  white light
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