Antinociceptive effect of ethanol extract of leaves of Lannea coromandelica |
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Authors: | Mohammad Zafar Imam Md Moniruzzaman |
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Institution: | Department of Pharmacy, Stamford University Bangladesh, 51, Siddeswari Road, Dhaka 1217, Bangladesh |
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Abstract: | Ethnopharmacological relevanceLannea coromandelica (Houtt.) Merr. is a plant locally called “Jiga”, found all over Bangladesh. Leaf of the plant is traditionally used in the treatment of local swellings, pains of body, toothache etc. This study evaluated the antinociceptive effect of the ethanol extract of L. coromandelica leaves (EELC).Materials and methodsThe antinociceptive activity of the extract (at the doses of 50, 100, and 200 mg/kg) was evaluated by using chemical- and heat-induced pain models such as acetic acid-induced writhing, hot plate, tail immersion, formalin, and glutamate test. To verify the possible involvement of opioid receptor in the central antinociceptive effect of EELC, naloxone was used to antagonize the effect. Besides, the involvements of ATP-sensitive K+ channel and cGMP pathway were also justified by using glibenclemide and methylene blue.ResultsEELC demonstrated significant dose-dependent antinociceptive activity in the chemical- and heat-induced nociception in mice models (p<0.05). These findings imply the involvement of both peripheral and central antinociceptive mechanisms. The use of naloxone confirmed the association of opioid receptors in the central antinociceptive effect. EELC also showed the involvements of ATP-sensitive K+ channel and cGMP pathway for antinociceptive activity.ConclusionsThis study reported the antinociceptive activity of the leaf of L. coromandelica and rationalized the traditional use of the leaf in the treatment of different painful conditions. |
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Keywords: | Lannea coromandelica Anacardiaceae Medicinal plant Pain Analgesic |
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