Effects of inhalable microparticle of flower of Lonicera japonica in a mouse model of COPD |
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| Authors: | Yang-Chun Park Mirim Jin Seung-Hyung Kim Min-Hee Kim Uk Namgung Yoon Yeo |
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| Affiliation: | 1. College of Oriental Medicine, Daejeon University, 96-3 Yongwun-dong, Daejeon 300-716, South Korea;2. East-West Biological Science Institute, Daejeon University, 96-3 Yongwun-dong, Daejeon 300-716, South Korea;3. College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA;4. Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA |
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| Abstract: | Ethnopharmacological relevance: Flower of Lonicera japonica (FLJ) is a traditional herbal medicine widely used in East Asia as an anti-inflammatory and anti-oxidative agent. The purpose of this study is to develop an inhalable powder formulation of FLJ and to evaluate its biological effects in a mouse model of chronic obstructive pulmonary disease (COPD). |
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| Keywords: | ACI, Anderson cascade impactor BALF, bronchoalveolar fluid COPD, chronic obstructive pulmonary disease CSS, cigarette smoke solution FBS, fetal bovine serum FPF, fine particle fraction FLJ, flower of Lonicera japonica FLJmp, FLJ microparticle H& E, hematoxylin&ndash eosin HPLC, high pressure liquid chromatography LPS, lipopolysaccharide MMAD, mass median aerodynamic diameter M-T, Masson-trichrome MMPs, matrix metalloproteinases PAS, periodic acid-Schiff SD, standard deviation |
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