耐甲氧西林金葡菌的临床分离率及其耐药性分析

目的 了解成都地区耐甲氧西林金黄色葡萄球菌（MRSA）耐药情况。方法 应用琼脂平皿二倍稀释法，测定万古霉素等12种抗菌药物对成都地区分离到的272株金黄色葡萄球菌（SA）的最低抑菌浓度（MIC）。结果 MRSA占临床分离SA的31.6%。MSSA除对青霉素，克拉霉素，氧氟沙星和环丙沙星部分耐药外，对其他所测抗菌药物均基本敏感，MRSA除对万古霉素敏感外，对其它抗生素均显示出不同程度的耐药。结论 MRSA对克拉霉素的耐药率最高（95.4%)，以下依次为环丙沙星（55.8%)，氧氟沙星（50.0%)，氨苄青霉素/舒巴坦（39.5%)。头孢唑啉以下依次为环丙沙星（55.8%)。氧氟沙星（50.0%)。氨苄青霉素/舒巴坦（39.5%)。头孢唑啉（36.1%)，头孢噻肟（30.3%)。利福平（27.9%)亚胺培南(17.5%)和阿米卡星（8.1%)。

Prevalence of methicillin-resistant Staphylococcus aureus(MRSA) and its resistance to antimicrobial agents

Objective In order to know the resistance of to antimicrobial agents and its distribution.Methods The minimal inhibitory concentrations(MICs) of 12 kinds of antimicrobial agents against 272 strains of Staphylococcus.aureus were tested by serial two fold agar dilution method.Results The comparison of resistance of MRSA and MSSA strains indicated that there's obvious difference between them, MSSA strains were sensitive to most of antimicrobial agents tested.However,MRSA strains were resistant to most of them.Conclusion The resistant rate of MRSA to clarithromycin is the highest(95.4%),followed by ciprofloxacin(55.8%),ofloxacin(50.0%),amoxicillin/clavulanic acid(39.5%),cefazolin36.1%),cefotaxime(30.3%),rifampin(27.9%),imipemen/cilastatin(17.5%)and amikacin(8.1%).