| 白血病细胞相关抑制物对红细胞系造血影响的初步探讨 |
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| 引用本文： | 黄仁魏,梁锦华,李明权,廖适生. 白血病细胞相关抑制物对红细胞系造血影响的初步探讨[J]. 中山大学学报(医学科学版), 1992, 0(3) |
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| 作者姓名： | 黄仁魏 梁锦华 李明权 廖适生 |
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| 作者单位： | 中山医科大学附属第三医院血液病研究室(黄仁魏，梁锦华，李明权)，中山医科大学附属第三医院血液病研究室(廖适生) |
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| 摘 要： | 本文以体外红系祖细胞培养方法。观察白血病细胞相关抑制物对正常红系祖细胞(CFU-E)的抑制作用。10/10例初发未治急性白血病病人的白血病细胞培养液对CFU-E的生长均有抑制,抑制率25.4～67.4％,平均抑制率为44.35％。结果提示,白血病细胞相关抑制物对正常红细胞系造血也有抑制作用。
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| 关 键 词： | 红系祖细胞(CFU-E) 白血病细胞条件培养液(LCCM) 白血病细胞相关抑制物 (LAI) |
THE STUDY OF THE INFLUENCE OF LEUKEMIC-CELL ASSOCIATED INHIBITOR ON NORMAL CFU-E |
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| Huang Renwei Liang Jinhua Li Mingquan Liao Shisheng. THE STUDY OF THE INFLUENCE OF LEUKEMIC-CELL ASSOCIATED INHIBITOR ON NORMAL CFU-E[J]. Journal of Sun Yatsen University(Medical Sciences), 1992, 0(3) |
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| Authors: | Huang Renwei Liang Jinhua Li Mingquan Liao Shisheng |
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| Abstract: | The in vitro CFU-E culture was used to research the suppression of leukemic-cell associated inhibitor on CFU-E. The influence of Leukemic Cell Conditioned Media(LCCM) from 10 cases of untreated acute leukemia patients was reported. 10/10 LCCM specimen showed inhibition on normal CFU-E growth in vitro. The inhibition rate ranged from 25.4% to 67.% with the mean of 44.35%. The result indicates that leukemic cell-associated inhibitor also has inhibitory activity on normal erythropoiesis. |
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| Keywords: | colong forminy unit-erythrocyte(CFU-E) leukmic cell conditioned media (LCCM) leukemic-cell associated inhibitor(LAI) |
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