Circulating MicroRNAs: a Potential Biomarker for Cardiac Damage,Inflammatory Response,and Left Ventricular Function Recovery in Pediatric Viral Myocarditis |
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Authors: | Lior Goldberg Tal Tirosh-Wagner Amir Vardi Haya Abbas Nir Pillar Noam Shomron Yael Nevo-Caspi Gideon Paret |
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Institution: | 1.Department of Pediatric Critical Care Medicine,Safra Children’s Hospital, Sheba Medical Center,Tel Hashomer,Israel;2.Faculty of Medicine,Tel-Aviv University,Tel-Aviv,Israel |
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Abstract: | Viral myocarditis (VM) can be a life-threatening event resulting in cardiac failure, chronic cardiomyopathy, and death. VM typically includes three phases, i.e., acute, subacute, and resolution/chronic. We prospectively investigated cardiac- and inflammatory-associated plasma-circulating miRNA levels in eight pediatric patients with VM during the three stages of the disease. The level of cardiac-associated miR-208a was significantly elevated during the acute phase compared with the subacute and resolution/chronic phases. The level of cardiac- and inflammatory-associated miR-21 was significantly elevated during the acute phase compared to the resolution/chronic phase. Moreover, cardiac-associated miR-208b levels during the subacute phase correlated with systolic left ventricular function recovery as measured during the resolution/chronic phase. The findings of our study demonstrate an association between cardiac damage and the inflammatory response and the expression of miR-208a and miR-21 during the pathological progression of myocarditis. We also found that miR-208b levels exhibit a prognostic significance for left ventricular functional recovery. |
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