复方甘草酸苷预防消化道肿瘤化疗后肝脏和血液系统毒性的临床观察

目的:观察复方甘草酸苷注射液预防消化道肿瘤化疗后肝脏和血液系统毒性的疗效。方法:回顾性分析在我院接受治疗的84例消化道肿瘤化疗患者,按所接受的治疗方案分为两组。对照组40例,给予常规化疗,基本化疗用药采用含有5-氟尿嘧啶、顺铂、阿霉素、紫杉醇等药物的方案,包括TCF、FAM、DF、ECF等化疗方案各2⁴个周期;治疗组44例,在对照组治疗基础上加用复方甘草酸苷注射液160 mg、qd。观察化疗前后两组患者呕吐、纳差、腹胀、肝区疼痛、乏力的症状、体征以及肝功能、血常规相关指标的变化。结果:与对照组比较,治疗组能显著改善患者的不适症状及体征,降低血清丙氨酸氨基转移酶、天冬氨酸氨基转移酶、总胆红素、谷氨酰转肽酶等肝功能指标,并升高白细胞、中性粒细胞数量,差异有统计学意义(P<0.05)。结论:复方甘草酸苷可减轻消化道肿瘤化疗后的肝脏毒性和白细胞损伤。

Clinical Observation of Compound Glycyrrhizinate for the Prevention of Liver and Hematological System Toxicity after Chemotherapy for Digestive Tract Cancer

OBJECTIVE： To observe therapeutic efficacy of Compound glycyrrhizinate injection for the prevention of liver and hematological system toxicity after chemotherapy for digestive tract cancer. METHODS： A total of 84 patients with digestive tract can- cer treated by chemotherapy were analyzed retrospectively and then divided into 2 groups according to different treatment approaches, 40 patients in control group received routine chemotherapy, and chemotherapy drugs involved 5-fluorouracil, cisplatin, adriamycin, paclitaxel, etc., including 2-4 cycles of TCF, FAM, DF, ECF and other chemotherapy plans. 44 patients in treatment group were ad- ditionally treated with Compound glycyrrhizinate injection 160 mg, qd on the basis of control group. Symptoms and signs as vomit- ing, anepithymia, abdominal distension, hepatalgia and fatigue, related index of liver function and blood routine were observed in 2 groups before and after chemotherapy. RESULTS： Compared with control group, indisposed symptoms and signs of patients could be improved significantly in treatment group. ALT, AST, TBIL, GGT and other liver function indicators were lowered, while the num- ber of white blood cell and neutrophile granulocyte were increased; there was statistical significance （P〈0.05）. CONCLUSIONS： Compound glycyrrhizinate can relieve the liver toxicity and white blood cell injury after chemotherapy for digestive tract cancer.