首次与多次住院精神分裂症患者抗精神病药使用调查

目的:了解首次住院与多次住院精神分裂症患者的抗精神病药用药情况。方法:采用一日法,对我院首次与多次住院精神分裂症患者抗精神病药使用情况进行调查,并对两者的调查结果进行比较。结果:在药物使用种类上,首次与多次住院患者使用频率排前5位的均为非典型性抗精神病药,首次住院患者用药频率最高的是奥氮平,多次住院患者用药频率最高的是氯氮平;首次住院精神分裂症患者在单一用药及非典型抗精神病药物的使用率上明显高于多次住院患者,差异均有统计学意义(P<0.05);在合并苯海索片、心境稳定剂、抗抑郁药、苯二氮类药上,两者差异无统计学意义。结论:我院首次住院精神分裂症患者在单一用药及非典型抗精神病药物的使用率上均高于多次住院患者,氯氮平较少用于首次住院患者。

Survey on the Application of Antipsychotic Drugs in Schizophrenic Inpatients Admitted for the First Time or Multiple Times

OBJECTIVE： To learn the application of antipsychotic drugs in schizophrenic inpatients for the first time or multi- ple times. METHODS： The application of psychotropic drugs in schizophrenic patients admitted for the first time and multiple times in our hospital was investigated using one day method, and their survey results were compared. RESULTS： Top 5 drugs used commonly were atypical antipsychotic drugs. The frequency of olanzapine use was the highest for first admission, while that of clo- zapine was the highest for multiple admission. The utilization rate of single drug and atypical antipsychotics in schizophrenic pa- tients admitted for the first time were significantly higher than that of schizophrenic patients admitted for multiple times. There was statistically significance （P〈0.05）. There was no statistical significance in the combination of Trihexyphenidyl tablets, mood stabi- lizers, BZD and anti-depressant drugs. CONCLUSIONS： The utilization rate of single drug and atypical antipsychotics in schizo- phrenic patients admitted for the first time is significantly higher than that of schizophrenic patients admitted for multiple times in our hospital. Clozapine is seldom used in the inpatients admitted for the first time.