益气复脉注射液与银杏叶提取物注射液治疗急性脑梗死的疗效比较

目的:比较益气复脉注射液与银杏叶提取物注射液治疗急性脑梗死的疗效和安全性。方法:将140例急性脑梗死患者按随机数字表法均分为对照组和研究组。两组患者均给予鼻管吸氧、鼻饲流质饮食、低脂饮食、促脑细胞代谢药、抗脑水肿、控制血压、防止感染等常规治疗。在此基础上,对照组患者给予银杏叶提取物注射液25 ml加入5%葡萄糖注射液250 ml中静脉滴注,每日1次;研究组患者给予益气复脉注射液40 ml加入5%葡萄糖注射液200 ml中静脉滴注,每日1次。两组患者疗程均为14 d。比较两组患者的临床疗效,治疗前后脑梗死体积、神经功能缺损(NFDS)评分、白细胞介素(IL)-6、IL-8、C反应蛋白(CRP)水平及不良反应发生情况。结果:治疗后研究组患者总有效率显著高于对照组,两组比较差异有统计学意义(P<0.05)。治疗前两组患者各项指标比较,差异均无统计学意义(P>0.05);治疗后两组患者NFDS评分、IL-6、IL-8、CRP均显著低于同组治疗前,且研究组低于对照组,脑梗死体积大于同组治疗前,但研究组增加的幅度低于对照组,差异有统计学意义(P<0.05)。研究组患者不良反应发生率显著低于对照组,两组比较差异有统计学意义(P<0.05)。结论:益气复脉注射液治疗急性脑梗死较银杏叶提取物注射液疗效更显著,且安全性较好。

Comparison of Therapeutic Efficacy of Yiqi Fumai Injection and Ginkgo Biloba Extract Injection on Acute Cerebral Infarction

OBJECTIVE：To compare the clinical efficacy and safety of Yiqi fumai injection and Ginkgo biloba extract injection in the treatment of acute cerebral infarction. METHODS：140 patients with cerebral infarction were randomly divided into control group and research group. Both groups received routine treatment as oxygen inhalation through nasal catheter,liquid diet by nasal feeding,low fat diet,agent for promoting cerebral cell metabolism,anti-encephaledema treatment,blood control,infection prevention. Control group additionally received Ginkgo biloba extract injection 25 ml added into 5% Glucose injection 250 ml intravenously,once a day. Research group was additionally given Yiqi fumai injection 40 ml added into 5% Glucose injection 200 ml intravenously,once a day. Treatment course of 2 groups lasted for 14 days. Clinical efficacies of 2 groups were observed,and cerebral infarction volume,neurological function defect score（NFDS）,serum IL-6 and IL-8,c-reactive protein（CRP）and ADR were observed before and after treatment. RESULTS：Total effective rate of research group was significantly than that of control group;there was statistical significance（P〈0.05）. There was no statistical significance in all index between 2 groups before treatment（P〉0.05）. NFDS,the levels of IL-6 and IL-8,CRP of 2 groups after treatment were significantly lower than before,and the research group was lower than the control group. The volume of cerebral infarction was increased,but the increase of research group was lower than that of control group;there was statistical significance（P〈0.05）. The incidence of ADR in research group was significantly lower than in control group;there was statistical significance（P〈0.05）. CONCLUSIONS：Yiqi fumai injection is more effective and safer than Ginkgo biloba extract injection in the treatment of acute cerebral infarction.