Clinical and pathological study on the hyperbaric oxygenation treatment ofchronic hepatitis |
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Authors: | Wei Zhao Wei Liu |
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Institution: | 1. Department of Medicine, Nanjing Second Hospital, Zhongfu Road 1-1, Nanjing 210003, Jiangsu Province, China 2. Department of Pathology, Nanjing Second Hospital, Zhongfu Road 1-1, Nanjing 210003, Jiangsu Province, China |
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Abstract: | AIM To study the effect and alteration of hepatic blood flow as well as ultrastructure of hepatic tissue inchronic cholestatic hepatitis after hypebaric oxygenation (HBO).METHODS Using the hepatic rheometer and Doppler B-mode ultrasound equipment, the contractive waveof hepatic blood flow and blood flow of portal vein were tested; the biochemistry, immunohistochemistryand ultrastructure of hepatic tissue were determined and served as the evaluating indexes.RESULTS After the HBO treatment, the contractive wave of hepatic blood-flow in 76% patients and bloodof right portal vein in 70% patients were increased, the improvement of serum ALT and BILI was 88.9%and 93.3% respectively. In addition, the swelling mitochondria, cholestasis of hepatic cells and capillariesreduced obviously; Kupffer's cells decreased. There was significant difference (t=2.85, P<0.05) beforeand after HBO treatment.CONCLUSION It is suggested that the HBO could increase the blood flow of portal vein and arteries,improve the hepatic function, cholestatsis and inflammation. |
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Keywords: | hyperbaric oxygenation hepatitis liver ultrastmcture |
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