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Macrophage activation syndrome in malaria |
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| Authors: | Rashna Dass Himesh Barman Sourabh Gohain Duwarah Vivek Choudhury Pankaj Jain Nayan Mani Deka Manjula Murari |
| Affiliation: | (1) Department of Paediatric Disciplines, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS), Room no. 218, Mawdiangdiang, Shillong, 793018, India;(2) Department of Pathology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India |
| Abstract: | Macrophage activation syndrome (MAS) is a clinical syndrome caused by an excessive proliferation of T lymphocytes and well-differentiated macrophages; an entity distinct from malignant histiocytosis. Although rheumatologic conditions are the common cause of MAS, a wide range of infections are also seen to cause MAS. We report an adolescent with severe Plasmodium falciparum malaria and MAS. He fulfilled six out of eight criteria required to diagnose hemophagocytic lymphohistiocytosis. |
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