Increased Extracellular Survivin in the Synovial Fluid of Rheumatoid Arthritis Patients: Fibroblast-like Synoviocytes as a Potential Source of Extracellular Survivin |
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Authors: | Joong Kyong Ahn Ji-Min Oh Jaejoon Lee Eun-Kyung Bae Kwang-Sung Ahn Hoon-Suk Cha Eun-Mi Koh |
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Institution: | (1) Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 108, Pyoung-Dong, Jongro-Ku, Seoul, Republic of Korea;(2) Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Gangnam-gu, Seoul, 135-710, Republic of Korea;(3) Center for Molecular Medicine, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; |
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Abstract: | Survivin belongs to the family of inhibitor of apoptosis proteins and plays an important role in the hyperplastic growth of
tissues and tumors. In this study, we assessed the expression of survivin in rheumatoid synovial fluids (SF) and synovial
tissues (ST) of rheumatoid arthritis (RA) patients in order to investigate the role of extracellular survivin in the pathogenesis
of RA. The survivin level from SF was significantly higher in RA patients (n = 38) than in osteoarthritis patients (n = 18; 10.68 ± 2.76 vs. 1.0 ± 0.56 pg/ml, p = 0.02). In addition, SF survivin level was higher in erosive RA patients (n = 23) than in non-erosive RA patients (n = 15; 15.26 ± 4.26 vs. 4.47 ± 1.12 pg/ml, p = 0.05). SF survivin level in RA was positively correlated with disease activity score 28, but did not reach statistical
significance (r = 0.309, p = 0.07). RA SF survivin level was also positively correlated with peripheral blood leukocyte counts (r = 0.443, p = 0.005). The immunohistochemical staining and Western blot analysis revealed survivin expression in the ST and fibroblast-like
synoviocytes of RA patients, respectively. These findings suggest that extracellular survivin may be produced from rheumatoid
FLS and may play an important role in the destructive RA process. |
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