| 卡马西平与TRH抗癫痫作用相互关系的研究 |
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| 引用本文： | 唐吉友,李湘萍,迟兆富,冯亚波. 卡马西平与TRH抗癫痫作用相互关系的研究[J]. 临床神经病学杂志, 2000, 13(4): 216-218 |
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| 作者姓名： | 唐吉友 李湘萍 迟兆富 冯亚波 |
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| 作者单位： | 250012,山东医科大学附属医院神经内科 |
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| 摘 要： | 目的探讨卡马西平与促甲状腺素释放激素（ＴＲＨ）抗癫痫作用的相互关系。方法采用放射免疫分析法测定戊四氮（ＰＴＺ）急性致病大鼠海马ＴＲＨ的含量。结果急性致痫后，海马内ＴＲＨ表达水平在２小时未见明显变化，４８小时显著升高。卡马西平预处理组在痫性发作后４８小时海马内ＴＲＨ表达水平明显升高，与对照组及假模型组相比均有显著性差异。结论卡马西平能显著升高痫性发作对ＴＲＨ的诱导表达，ＴＲＨ与卡马西平的作用可能有重
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| 关 键 词： | 癫痫 卡马西平 TRH 放射免疫分析 治疗 |
A study on the relationship of antiepileptic effect between carbamazepine and thyrotropin releasing hormone |
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| Tang Jiyou,Li Xiangping,Chi Zhaofu,et al.. A study on the relationship of antiepileptic effect between carbamazepine and thyrotropin releasing hormone[J]. Journal of Clinical Neurology, 2000, 13(4): 216-218 |
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| Authors: | Tang Jiyou Li Xiangping Chi Zhaofu et al. |
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| Affiliation: | Tang Jiyou,Li Xiangping,Chi Zhaofu,et al.Department of Neurology,the Affiliated Hospital of Shandong Medical University,Jinan 250012 |
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| Abstract: | Objective To investigate the relationship of antiepileptic effect between carbamazepine (CBZ) and thyrotropin releasing hormore(TRH).Methods The content of TRH in hippocampus in rats were examined by radioimmunoassay (RIA) after PTZ induced seizure.Results After PTZ induced seizures,there was no obvious change on the expression of TRH in hippocampus in 2 h,but it was significantly elevated in 48 h.The expression of TRH in hippocampus was increased obviously 48 h after seizure in CBZ pretreatment group, there was remarkable difference as compared with the controls and the pseudomodel group.Conclusion CBZ could elevate obviously the expression of TRH after seizure, which suggested the potential overlapping or additive influences of TRH and CBZ. |
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| Keywords: | Epilepsy Carbamazepine Thyrotropin releasing hormone Radioimmunoassay |
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