| 硫色满酮3位Mannich碱衍生物的合成及其抗真菌活性 |
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| 引用本文： | 齐平,靳颖华,郭春,方林.硫色满酮3位Mannich碱衍生物的合成及其抗真菌活性[J].中国药物化学杂志,2003,13(3):134-137. |
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| 作者姓名： | 齐平 靳颖华 郭春 方林 |
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| 作者单位： | 1. 北京军区总医院药剂科,北京,100700
2. 沈阳药科大学制药工程学院,辽宁,沈阳,110016 |
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| 基金项目： | 辽宁省自然科学基金项目 (2 0 0 2 2 0 5 3)，沈阳市高科技创业种子基金项目 (0 2Z0 10 0 5 5 ) |
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| 摘 要： | 目的 设计、合成硫色满酮3位Mannich碱类化合物，并对其抗真菌活性进行初步评价。方法 以对氟苯硫酚为原料，经多步反应合成目标化合物，并测定目标化合物的抗真菌活性。结果共合成了10个未见文献报道的新化合物，经红外光谱、核磁共振氟谱及元素分析确证了其结构。其中化合物3对大部分供试真菌活性强于或相当于对照品克霉唑。结论 硫色满目3位取代Mannich碱具有较强的抗真菌活性。
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| 关 键 词： | 药物化学 制备 化学合成 硫色满酮 Mannich碱 抗真菌活性 |
| 文章编号： | 1005-0108(2003)03-0134-04 |
Synthesis and antifungal activities of the Mannich bases of thiochromanones |
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| QI Ping ,JIN Ying-hua ,GUO Chun ,FANG Lin.Synthesis and antifungal activities of the Mannich bases of thiochromanones[J].Chinese Journal of Medicinal Chemistry,2003,13(3):134-137. |
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| Authors: | QI Ping JIN Ying-hua GUO Chun FANG Lin |
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| Institution: | QI Ping 1,JIN Ying-hua 1,GUO Chun 2,FANG Lin 2 |
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| Abstract: | Aim To design and synthesize the Mannich bases of thiochromanones,and to study their antifungal activity. Methods The target compounds were synthesized from the p -fluorothiophenols,and tested for their antifungal activities in vitro . Results Ten new compounds were synthesized.The structures of these compounds were confirmed by IR, 1H-NMR and elemental analysis.The compound 3 gave excellent antifungal activity and its MIC value was below or equal to that of the control. Conclusion The Mannich bases of thiochromanones have good antifungal activity. |
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| Keywords: | medicinal chemistry preparation chemical synthesis thiochromanones Mannich bases antifungal activity |
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