胃癌及癌前病变中表皮生长因子和受体表达的研究

目的 探讨表皮生长因子（ＥＧＦ）和表皮生长因子受体（ＥＧＦＲ）在胃癌的表达及与胃癌发生发展的关系。方法 采用免疫组化Ｓ－Ｐ法对正常胃粘膜（ｎ＝５），各组胃粘膜异型增生（轻度ｎ＝９，中度ｎ＝６，重度ｎ＝５），早期胃癌（ｎ＝１０），进展期胃癌（ｎ＝４０），癌旁组织（ｎ＝２７）进行研究。结果 ＥＧＦ及ＥＧＦＲ在正常胃粘膜中均为阴性，在异型增生病变中随异型增生程度的增加，阳性率逐渐升高。ＥＧＦ在轻、中、重

Expression of Epidermal Growth Factor and its Receptor in Gastric Carcinoma and Precancerous Lesions

Objectire To study the expression and significance of EGF and EGFR in the Process of gastric carcinogenisis. Methods: S- P im- munohistochemical method was used to examine the expression of EGF and EGFR in 75cases (5 normal gastric mucosas, 20 gastric mucosas, 50 gastric carcinomas and 27 paracarcinomas tissues). Results:Normal gastric mucosa was negative for EGF and EGFR. Increased expression of EGF and EGFR was found in slight,moderate and severe dysplasia. EGF expreession was 22.2%,50% and 80%, EGFR expression was 33.3%, 66. 7% and 60%. The positive rates of EGF and EGFR in early gastric carcinomas were both 20%. The positive rates of EGF and EGFR in advanced gastric carcinomas were 62. 5% and 60% respectivly. The positive rates of EGF and EGFR in advanced gastric carcinomas were significantly high- er than those in early gastric carcinomas (P < 0. 05). The positive rates of EGF and EGFR in paracarcinomas abnomal tissues were significantly higher than those in paracarcinomas nomal tissues (77. 8% vs 22.2%, P <0.05. 83.3% vs 44.4%, P <0.05). Conclusion:EGF and EGFR positive expression might play an important role in the process of carcinogenesis of gastric mucosa and might serve as an important molecular marker of gastric premalignant lesions.