| 外泌体在急性心肌梗死诊疗中的研究进展 |
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| 引用本文： | 王佳怡,庄少伟.外泌体在急性心肌梗死诊疗中的研究进展[J].同济大学学报(医学版),2021,42(6):860-866. |
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| 作者姓名： | 王佳怡 庄少伟 |
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| 作者单位： | 上海中医药大学附属第七人民医院心血管内科,上海 200137 |
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| 基金项目： | 上海市浦东新区科技发展基金民生科研专项资金医疗卫生项目(PKJ2018-Y15);上海市卫生健康委员会科学研究项目 (201940461) |
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| 摘 要： | 急性心肌梗死(acute myocardial infarction, AMI)是冠状动脉突发的、持续性缺血缺氧导致的心肌损伤过程，众多证据表明外泌体在AMI过程中发挥重要的作用。外泌体作为细胞外囊泡的一员，通过多种信息分子传递细胞间信号，从而介导多种病理生理过程。本文以外泌体内不同种信号传递物质作为切入点，探讨外泌体在对AMI诊治过程中的影响，并讨论其在AMI诊疗过程中的展望。
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| 关 键 词： | 急性心肌梗死 外泌体 细胞间信号传递 生物标志物 |
| 收稿时间： | 2021/5/17 0:00:00 |
Research progress of exosomes in acute myocardial infarction |
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| WANG Jia-yi,ZHUANG Shao-wei.Research progress of exosomes in acute myocardial infarction[J].Journal of Tongji University(Medical Science),2021,42(6):860-866. |
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| Authors: | WANG Jia-yi ZHUANG Shao-wei |
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| Abstract: | Acute myocardial infarction is the myocardial damage caused by coronary ischemia and hypoxia. A lot of research evidence have shown that exosomes play an important role in the development of acute myocardial infarction. As a member of extracellular vesicles, exosomes carry information molecules that transmit intercellular signals and mediate a variety of pathophysiological processes. This article reviews the different kinds of signal transmitting proteins inside the exosomes, and their effects on the process of acute myocardial infarction; also discuss the potential application of exosomes in the diagnosis and treatment of acute myocardial infarction. |
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| Keywords: | acute myocardial infarction exosome intercellular signal transmission biomarker |
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