肺移植冷缺血时间与支气管吻合口狭窄的相关性研究

目的：肺移植供体冷缺血时间与术后支气管吻合口狭窄的相关性有待进一步研究,回顾总结肺移植供体冷缺血时间对术后支气管吻合口狭窄发生率的影响,改善手术效果及患者预后。方法回顾分析2009年至2012年首都医科大学附属北京朝阳医院22例患者生存期〉1年的肺移植手术供体冷缺血时间和受者术后支气管镜检查报告,根据供肺冷缺血时间所有受者分为冷缺血时间〈6 h 组和〉6 h 组。进一步分析冷缺血时间〉6 h 对术后支气管吻合口狭窄发生率的影响。结果22例肺移植患者中,供肺冷缺血时间〉6 h 组支气管吻合口狭窄发生率要高于〈6 h 组（P=0.003）,2组其他各指标比较,差异均无统计学意义。结论提示严格控制供肺冷缺血时间可以有效防止移植术后支气管吻合口狭窄的发生,从而提高肺移植成功率,改善患者生存情况。

Correlation between cold ischemia time and bronchial anastomotic stenosis

Objective With the development of lung transplantation, the relationship between cold ischemia time and bronchial anastomotic stenosis requires further study. This study aimed to improve the prognosis of patients who received lung transplantation by studying the effect of cold ischemia time on bronchial anastomotic stenosis. Methods We respectively analyzed medical records of the patients, having received lung transplantation from 2009 to 2012, including the surgical records and the reports bronchoscope. Results The incidence of bronchial anastomotic stenosis of the group, of which cold ischemia time was less than 6 hours, was higher than the group of which cold ischemia time was longer than 6 hours. Conclusion The results suggest that control of lung cold ischemia time can effectively prevent the occurrence of bronchial anastomotic stenosis after lung transplantation and improve survival of patients.