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| 白细胞介素-8-251T/A基因多态性和肺癌易感性的 Meta 分析 | |
| 引用本文： | 真德智,王晓彬,李云松,李杰,韩毅,刘志东. 白细胞介素-8-251T/A基因多态性和肺癌易感性的 Meta 分析[J]. 首都医科大学学报, 2014, 0(6): 711-716 |
| 作者姓名： | 真德智 王晓彬 李云松 李杰 韩毅 刘志东 |
| 作者单位： | 1. 首都医科大学附属北京胸科医院/ 北京市结核病胸部肿瘤研究所胸外科,北京,101149 2. 内蒙古林业总医院胸心血管外科,内蒙古牙克石,022150 3. 首都医科大学附属北京胸科医院/ 北京市结核病胸部肿瘤研究所肿瘤科,北京,101149 |
| 基金项目： | 北京市科学技术委员会科技计划资助项目(Z131107002213048)。 This study was supported by Scientific Project of Beijing Municipal Sci-ence and Technology Commission |
| 摘 要： | 目的：本研究对白细胞介素-8-251 T/ A（interleukin-8-251 T/ A,IL-8-251 T/ A）（rs4073）与肺癌发生风险相关性文献进行Meta 分析来评价两者相关性特征。方法检索2013年12月1日之前 PubMed 中白细胞介素-8-251 T/ A（interleukin-8-251 T/ A, IL-8-251T/ A）（rs4073）基因多态性与肺癌发生风险相关性病例对照研究的文献。应用 Stata11.0软件合并计算 A/ A 纯合子和携带 A 等位基因（ T/ A ＋ A/ A）杂合子与野生型 T/ T 纯合子肺癌发生的比值比（ odds ratios,OR）及95%置信区间（ confidence intervals,CI）,并按照亚裔与非亚裔人群进行亚组分析,评价 IL-8-251T/ A（rs4073）不同基因亚型与肺癌发生的相关性及与不同种族肺癌发生的相关性。结果共有6篇文献符合纳入标准。合并计算所有纳入文献中的 IL-8-251T/ A（rs4073）A/ A 纯合子和携带 A 等位基因（T/ A＋A/ A）杂合子与野生型 T/ T 纯合子肺癌发生的 OR 值,肺癌组3265例 OR =1.03（95% CI =0.92~1.14,异质性 P=0.235）,对照组3607例 OR=1.07（95% CI=0.96~1.19,异质性 P=0.245）,IL-8-251T/ A（rs4073）基因多态性与肺癌发生无相关性。当按亚裔与非亚裔人群进行亚组分析后,发现亚裔人群中携带 A 等位基因（T/ A＋A/ A）杂合子（OR =1.48,95%CI=1.04~2.11,异质性 P=0.030）和 A/ A 纯合子（OR=1.35,95% CI=1.02~1.92,异质性 P=0.090）与 T/ T 纯合子肺癌发生风险有着显著的相关性。结论 IL-8-251T/ A（rs4073）基因多态性在全部人群中与肺癌发生风险无相关性,但是在亚裔人群中 A 等位基因的存在与肺癌发生显著相关。 |
| 关 键 词： | 白细胞介素-8 多态性 肺癌 易感性 Meta分析 |
Interleukin-8-251T/A gene polymorphism and lung cancer susceptibility:a meta-analysis |
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| Zhen Dezhi,Wang Xiaobin,Li Yunsong,Li Jie,Han Yi,Liu Zhidong. Interleukin-8-251T/A gene polymorphism and lung cancer susceptibility:a meta-analysis[J]. Journal of Capital Medical University, 2014, 0(6): 711-716 | |
| Authors: | Zhen Dezhi Wang Xiaobin Li Yunsong Li Jie Han Yi Liu Zhidong |
| Affiliation: | Zhen Dezhi, Wang Xiaobin, Li Yunsong, Li Jie, Han Yi, Liu Zhidong ( 1. Department of Thoracic Surgery, Beijing Chest Hospital, Capital Medical University/Bering Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China; 2. Department of Thoracic Cardiovascular Surgery, Inner Mongolia Forestry General Hospital, Yakeshi 022150, Inner Mongolia Autonomous Region, China; 3. Department of Oneology, Beijing Chest Hospital, Capital Medical University/ Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China) |
| Abstract: | Objective To perform a meta-analysis to evaluate the association between the interleukin-8-251T/ A（rs4073） gene polymorphism and lung cancer risk. Methods A literature search at PubMed was performed to identify case-control study articles published before December 1st, 2013. The Stata11.0 software was used to calculate the pooled odds ratios（OR） with 95% confidence intervals（CI）. And the analysis was stratified by Asian and non-Asian populations. Results Totally six articles met our inclusion criteria. The included studies yielded a total of 3 265 lung cancer cases and 3607 controls. For the homozygous A/ A and A allele carriers（T/ A ＋ A/ A）, the pooled ORs for all studies combining 3 265 cases and 3 607 controls were 1. 03（95% CI =0. 92-1. 14, P=0. 235 for heterogeneity） and 1. 07（95% CI =0. 96-1. 19, P=0.245 for heterogeneity） when compared with the homozygous wild-type genotype（T/ T）. When the analysis was stratified by Asian and non-Asian populations, significant risks were found among Asians for both the A allele carriers（OR = 1. 48, 95% CI = 1. 04-2. 11, P = 0. 030 for heterogeneity） and the homozygous A/ A（OR=1. 35, 95% CI =1. 02-1. 92, P=0. 090 for heterogeneity） individuals. However, no significant associations were found in non-Asian populations using any of the genetic models. Conclusion This Meta-analysis suggests that the interleukin-8-251 allele confer an increased risk for the development of lung cancer among Asians. |
| Keywords: | interleukin-8 polymorphism lung cancer susceptibility Meta-analysis |
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