Antimicrobial activity against strains of Escherichia coli and Klebsiella spp. with resistance phenotypes consistent with an extended-spectrum β-lactamase in Europe |
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Authors: | R N Jones M A Pfaller the MYSTIC Study Group |
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Institution: | Tufts University School of Medicine, Jones Group/JMI Laboratories, 345 Beaver Kreek Center, Suite A, North Liberty, Iowa 52317 and;University of Iowa College of Medicine, Iowa City, Iowa, USA;Tel: +1319 6653370 Fax: +1319 6653371 E-mail: |
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Abstract: | Extended-spectrum β-lactamases (ESBLs) have continued to evolve after their initial detection in Europe nearly two decades ago. The summary results from the MYSTIC Program (31 medical centers) were utilized to assess the extent of ESBL occurrence in Europe from 1997 to 2000. ESBL phenotype rates in Klebsiella spp. (32.8%) and Escherichia coli (14.4%) were generally stable, but extensive hospital-to-hospital and unit-to-unit variations were noted. The highest ESBL rates were found in eastern Europe (including Turkey) and in intensive care unit patient populations. Carbapenems remained active against the ESBL-producing strains (meropenem MIC90, 0.25–1 mg/L), while some other agents, such as aminoglycosides, fluoroquinolones, and piperacillin–tazobactam, were significantly less effective. International surveillance initiatives should be maintained to monitor future progression of this important resistance. |
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Keywords: | ESBL MYSTIC meropenem Klebsiella spp E coli |
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