| 复方参芪冲剂抗肿瘤作用 |
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| 引用本文： | 张玉芳,吴玉波,张永恒. 复方参芪冲剂抗肿瘤作用[J]. 中国临床药理学与治疗学, 1998, 0(1) |
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| 作者姓名： | 张玉芳 吴玉波 张永恒 |
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| 作者单位： | 哈尔滨医科大学肿瘤药物研究所!哈尔滨150040 |
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| 摘 要： | 目的观察复方参芪冲剂对小鼠S180、H22、Lewis肿瘤生长及与化疗药物阿霉素(ADM)、顺铂(DDP)、环磷酰胺(CTX)合用对抗肿瘤活性和免疫功能的影响。方法采用动物移植瘤S180、H22、Lewis模型 ,对复方参芪冲剂的抗肿瘤作用及对化疗药物的增效减毒作用进行检测。结果复方参芪冲剂对小鼠S180、H22、Lewis均有明显抑制作用 ,明显增强ADM、DDP、CTX的抗肿瘤活性 ,对其所引起的免疫抑制性有明显保护作用。结论复方参芪冲剂的抗肿瘤作用及对化疗药物的增效解毒作用 ,可能是通过增强机体的免疫功能实现的
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| 关 键 词： | 复方参芪冲剂 抗肿瘤 免疫功能 |
Antitumor effect of compound shenqi granule |
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| ZHANG Yu_Fang WU Yu_Bo ZHANG Yong_Heng. Antitumor effect of compound shenqi granule[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 1998, 0(1) |
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| Authors: | ZHANG Yu_Fang WU Yu_Bo ZHANG Yong_Heng |
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| Abstract: | Aim The influence of the compound Shenqi granule both on the growth of S180,H22,Lewis and on the antineoplastic activity as well as immunological function in combination with ADM,DDP and CTX was to be observed.Methods Antineoplastic activity of the compound and the synergia, detoxification of chemotherapy drugs were observed in mouse transplanted tumor models.Results It was revealed that the compound Shenqi granule Obviously decreaced the tumor of S180,H22,Lewis, increaced the antineoplasticactivity of ADM,DDP,CTX, and prevented the immusuppress induced by ADM, DDPand CTX.Conclusion The compound Shenqi granule has the properties of antineoplastic function and the synergia and detoxification which result from its enhance of immunological function. |
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| Keywords: | compound Shenqi granule antineoplastic activity immunological funtion |
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