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Evaluating the expression of CARMA3 as a prognostic tumor marker in renal cell carcinoma |
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| Authors: | Guang-Li Wu Jian-Lin Yuan Xu-Dong Huang Jun-Fang Rong Li-Xia Zhang Yue-Ping Liu Fu-Li Wang |
| Affiliation: | 1. Department of Nephrology, Bethune International Peace Hospital of People’s Liberation Army (PLA), No. 398, Zhongshan West Rd., Shijiazhuang, 050082, Hebei Province, China 2. Department of Urinary Surgery, Xijing Hospital, The Fourth Military Medical University, No. 17, Changle West Rd., Xi’an, 710032, Shaanxi Province, China 3. Department of Anesthesiology, Hebei Province General Hospital, Shijiazhuang, 050071, China 4. Department of Pathology, Tumor Hospital of Hebei Province, Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China |
| Abstract: | Increased expression of CARMA3 has been reported to be involved in tumorigenesis and tumor progression of several cancer types. The aim of our study is to investigate the prognostic role of CARMA3 expression in patients with renal cell carcinoma (RCC). Real-time quantitative PCR was performed to detect CARMA3 mRNA expression level in 31 paired samples of RCC and adjacent noncancerous renal tissues. Subsequently, extensive immunohistochemistry was performed to detect CARMA3 protein expression in 114 RCC cases. Clinicopathological data for these patients were evaluated. The prognostic significance was assessed using the Kaplan–Meier survival estimates and log-rank tests. CARMA3 mRNA expression was significantly higher in RCC tissues compared with adjacent noncancerous renal tissues (3.525?±?1.233 vs. 1.512?±?0.784, P?P?=?0.026), histological differentiation (P?=?0.039), tumor stage (P?=?0.006), and the presence of metastasis (P?P? |
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