| 上皮性卵巢癌组织E-cadherin mRNA表达临床意义的研究 |
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| 引用本文： | 廖娟,吴少勇.上皮性卵巢癌组织E-cadherin mRNA表达临床意义的研究[J].中华肿瘤防治杂志,2011,18(10):795-798. |
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| 作者姓名： | 廖娟 吴少勇 |
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| 作者单位： | 1. 南昌大学医学院临床医学系,江西南昌,330006
2. 江西省妇幼保健院妇科肿瘤科,江西南昌,330006 |
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| 基金项目： | 江西省科技厅基金资助(20053142) |
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| 摘 要： | 目的:研究E-钙黏附蛋白(E-cadherin,E-cad)mRNA在正常卵巢、上皮性卵巢良性肿瘤及上皮性卵巢癌组织中的表达,并探讨E-cad表达与上皮性卵巢癌临床病理特征的关系。方法:用荧光定量-PCR法(FQ-PCR)分别检测正常卵巢上皮组织、卵巢上皮性良性肿瘤以及上皮性卵巢癌组织中E-cad的表达水平。结果:E-cad在10例正常卵巢上皮组织中表达为0,阳性表达率0;在10例良性卵巢上皮性肿瘤组织中阳性表达为0.261 7±0.138 2,阳性表达率为100%;在30例恶性卵巢上皮性肿瘤组织中阳性表达为0.012 7±0.018 1,阳性表达率为50%;3组间比较差异有统计学意义,χ2=30.924,P<0.05。E-cad的表达与FIGO分期成负相关,r=-0.873,P<0.05;与患者的生存时间呈正相关,r=0.602,P<0.05。E-cad表达与其组织学类型无相关性,χ2=3.811,P>0.05;与病理分级无相关性,χ2=3.458,P>0.05。结论:E-cad可作为上皮性卵巢癌病情进展和预后判断的指标之一,为分子靶向治疗提供一个依据。
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| 关 键 词： | 卵巢肿瘤/病理学 钙结合蛋白质类 RNA 信使 聚合酶链反应 |
Expression of mRNA of E-cadherin in epithelial ovarian tumor and their significance |
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| LIAO Juan,WU Shao-yong.Expression of mRNA of E-cadherin in epithelial ovarian tumor and their significance[J].Chinese Journal of Cancer Prevention and Treatment,2011,18(10):795-798. |
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| Authors: | LIAO Juan WU Shao-yong |
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| Institution: | LIAO Juan1,WU Shao-yong2 1.Department of Clinical Medicine,Medical College of Nanchang University,Nanchang 330006,P.R.China2.Department of Gynecology Oncology,Maternal and Child Health Hospital of Jiangxi,P.R.China |
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| Abstract: | OBJECTIVE:To detect the expression of mRNA of E-cadherin(E-cad) in normal ovarian tissues,beningn ovarian tumor tissues and epithelial ovarian tumor,and the correlation between E-cad and epithelial ovarian tumor,and provide theoretical basis to clinical diagnosis and therapy.METHODS:The mRNA levels of E-cad were analyzed by FQ-PCR(Fish real time quantitative-polymerase chain reaction)in the fresh normal ovarian tissues,beningn ovarian tumor tissues,and epithelial ovarian carcinoma tissues.RESULTS: The expre... |
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| Keywords: | ovarian neoplasms/pathology calcium binding proteins RNA messenger polymerase chain reaction |
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