基于Fisher判别分析的多囊卵巢综合征中医证候分布规律

目的多囊卵巢综合征(polycystic ovary syndrome,PCOS)属慢性排卵功能障碍性疾病,以高雄激素血症及持续无排卵为特征。本文探讨Fisher判别分析(Fisher discriminant analysis,FDA)方法在多囊卵巢综合征中医证候分布规律中的应用以及证型与性激素水平的关系。方法中医诊断PCOS患者62例,临床辨证分为3组,其中包括肾虚证组21例、肾虚痰阻证组22例及肾虚肝郁证组19例。证型包括单证和兼夹证,需要采用二次分型的方法。先运用Logistic回归法将肾虚证分离出来,再运用Fisher判别分析法对剩余的兼夹证进行第二次分类。运用统计学方法分析证型与性激素水平的相关性。结果 Fisher判别分析法对PCOS兼夹证的分型的正确率为87.8%。肾虚痰阻证组黄体生成素(luteinizing hormone,LH)显著高于肾虚肝郁证组(P0.05),肾虚肝郁证组泌乳素(prolactin,PRL)显著高于肾虚痰阻证组(P0.05)。结论 Fisher判别函数模型检验结果与实际情况吻合良好,可以作为一种辅助工具来帮助研究PCOS中医证候分布规律。PCOS证型与性激素变化有相关性。

Distribution regularity of TCM syndromes in patients with polycystic ovary syndrome based on Fisher discriminant analysis

Objective Polycystic ovary syndrome (PCOS) is a chronic ovulation disorders and is characterized by hyperandrogenism and continuous anovulation.The objective is to discuss the application of Fishier discriminant analysis (FDA) on Chinese medicine syndrome type distribution in patients with PCOS and the relationship with sexual hormones between the symptoms.Methods Chinese medicine syndrome types of 62 PCOS patients were differentiated,including 21 cases with kidney deficiency syndrome,22 cases with kidney deficiency and phlegm stagnation syndrome and 19 cases with kidney liver depression syndrome.These cases covered single symptoms,accompanied symptoms and are separated with the method of twice grouping.The cases with kidney deficiency syndrome were separated with Logistic regression first,and then the remaining accompanied symptoms were for the second classification with Fishier discriminant analysis method.The correlation on sex hormones between the symptoms was analyzed with statistical method.Results Fishier discriminant analysis was used for the separation of accompanied symptoms and the correct rate was 87.8％.The luteinizing hormone (LH) level was significantly higher in the groups of kidney deficiency and phlegm stagnation syndrome than in the group of kidney liver depression syndrome(P＜0.05)and the prolactin (PRL) level was significantly higher in the group of kidney liver depression syndrome than in the group of kidney deficiency and phlegm stagnation syndrome (P＜0.05).Conclusions The test results of Fisher discriminant function model are in good agreement with those obtained from the actual situation,and may be used as an auxiliary tool for the exploration on Chinese medicine syndrome type distribution in patients with PCOS.There is a correlation between syndrome type and sexual hormone levels.