100例外阴白色病变患者危险因素的研究

目的 研究外阴白色病变的危险因素。方法 调查在中国医科大学第一临床学院就诊的外阴白色病变患者100例的临床资料，按1：1病例对照配比原则，选取工作方式、环境温度、饮食习惯、情绪、穿着内裤、自身免疫疾病、婚育史、产次、产伤、初潮年龄、经血量、外阴炎和尿道炎17个危险因素，进行单因素及多因素的logistic分析。结果 多因素1ogistic分析显示，最终有统计学意义的因素，按危险性大小排列依次为：常患尿道炎或阴道炎者，情绪易怒、易紧张者，产次增多和喜欢吃辣食者。伴有尿道炎或阴道炎的妇女外阴白色病变发生的危险性比无此症状者增大11．02或6．74倍；情绪易怒、易紧张者外阴白色病变发生的危险性比性格开朗的人增大4．27倍；产次增多或喜欢吃辣食者外阴白色病变发生的危险性比产次少或不喜欢吃辣食者增大3．37倍或2．55倍。结论 喜辣食者、易紧张或易怒者、产次增多、患阴道炎或尿道炎者是外阴白色病变的主要危险因素。

Study on the risk factors of 100 cases with vulvar dystrophy

OBJECTIVE: To assess the risk factors for vulvar dystrophy. METHODS: An epidemiological study was carried out. Data on 100 cases with vulvar dystrophy was reviewed and face to face interviewed with a uniform questionnaire including the manner of work, environmental temperature, habit of eating, mood, underwear wearing, autoimmune diseases, marriage, menstrual age, the quantity of menses, orders of pregnancy, and labor trauma of vulvar during delivery, vulvitis and urethritis ect. Univariable analysis and multivariate logistic regression analysis were carried out with 1:1 case-control methodology. RESULTS: Multiple conditional logistic regression analysis showed that vulvar dystrophy was positively associated with hot food (OR = 2.55, 95% CI: 1.24 - 5.25), mood (OR = 4.27, 95% CI: 1.96 - 9.29), order of pregnancy (OR = 3.37, 95% CI: 2.11 - 5.40), vulvitis (OR = 6.74, 95% CI: 2.66 - 17.09) and urethritis (OR = 11.02, 95% CI: 1.01 - 120.19). Vulviitis or urethritis increased 6.74 or 11.02 times the incidence of vulva dystrophy. Anger or nervous state contributed to the incidence of vulva dystrophy (OR = 4.27). Addict to hot food and order of labor also increased risk ratio for 2.55 and 3.37 times, respectively. CONCLUSION: The risk factors of vulvar dystrophy were: addict to hot food, often holding a angry or nervous state, increase of labors, having vulvitis and urethritis.