Influence of environmental enrichment on an object recognition task in CF1 mice |
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Authors: | Giordano Gubert Viola Paulo Henrique Botton Ana Paula Ardais Diogo Onofre Souza |
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Affiliation: | a Departamento de Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, 90035 003, Brazil b PPG-Saúde e Comportamento, Universidade Católica de Pelotas, Pelotas, RS, Brazil |
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Abstract: | Environmental enrichment (EE) is an experimental model for studying neuroplasticity. EE is used to investigate behavioral modifications associated with gene-environmental interaction. The object recognition task (ORT) evaluates animals' ability to learn about their environment, which depends on their innate instinct. By using young CF1 mice, the present study evaluated the effect of 8 weeks of EE on the ORT. Our results indicate that EE decreased the time the animals spent exploring familiar and unfamiliar objects and total time spent exploring both objects, without affecting the capacity of discrimination of objects. These findings indicate a more propitious behavior for species survival in animals subjected to EE, including rapid exploration and learning about the environment. |
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Keywords: | BDNF, brain-derived neurotrophic factor BSA, bovine serum albumin EE, environmental enrichment TrkB, tyrosine kinase receptor |
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