表皮生长因子受体在胃癌和食管癌中的表达及意义

目的 :研究表皮生长因子受体 (EGFR)在消化道肿瘤 ,尤其是胃癌中的表达及其临床意义。方法 :应用免疫组织化学技术 ,对胃癌、食管癌、大肠癌和良性对照组织标本中EGFR的含量进行定性检测 ,观察其与临床病理参数的关系。结果 :(1)在良性对照组中 ,EGFR的表达率为 2 3 0 8% ,明显低于各肿瘤组 (P <0 0 1)。(2 )在胃癌组、食管癌组和大肠癌组中 ,EGFR的表达率分别为 49 0 9%、6 5 0 0 %和 5 6 2 5 % ,相互之间经统计学处理 ,P >0 0 5。 (3)EGFR的表达与患者的性别、年龄、病变部位和大体分型无关 ,同时也与胃癌的组织学类型及其分化程度无关 (P >0 0 5 )。 (4)EGFR的表达与患者的临床分期、浸润深度及淋巴结转移情况相关 (P <0 0 5 )。结论 :EGFR的检测可作为判断肿瘤的恶性程度、预测淋巴结转移的趋势 ,可作为指导制定合理的治疗方案和预后评估的有益指标。

Expression of Epidermal Growth Factor Receptor(EGFR) in Gastric Cancer and Esophageal Cancer and Its Clinical Significance

Objective:To study the expression of EGFR and its clinical significance in gastrointestinal carcinoma, especially in gastric cancer. Methods: The expression of EGFR was qualitatively investigated by SABC immunohistochemical technique in gastric cancer, esophageal cancer and colorectal cancer. To explore its clinopathological correlation and its clinical significance. Results: (1)The positive rate of EGFR expression was 23.08% in benign group. The expression of EGFR was significantly lower in benign group than that in malignant tumor group.(2)The positive rate of EGFR expression was 49.09% in gastric cancer, 65.00% in esophageal cancer, 56.25% in colorectal cancer, respectively. There was no significant difference statistically (P>0 05).(3)The expression of EGFR was independent of sex, age, position of tumor and growth style in gastric cancer. Meanwhile, there was no significant relation to histological types and cell differentiation of tumor in gastric cancer (P>0.05). And (4) the expression of EGFR correlated with the clinical stages, serosal infiltration and metastasis perigastric lymph nodes in gastric cancer (P<0 05). Conclusion: These data suggest that detection of EGFR would be of benefit in reflecting the malignant degree, indicating lymph node metastasis, guiding treatment and evaluating tumor prognosis.