P-选择素和胰岛素抵抗对糖尿病肾病的影响

目的 研究P-选择素、胰岛素抵抗（IR）与糖尿病肾病（DN）的关系。方法 对109例2型糖尿病（T2DM）患者（有肾病者为DN组、无肾病者为DM组）和正常对照组（NC），进行空腹血糖（FPG）、胰岛素、P-选择素测定，计算HOMA法胰岛素抵抗指数（HOMA-IR）。结果 DN和DM组血中的FPG、胰岛素、P-选择素及HOMA-IR均高于NC组（P〈0.01），且DN组上述结果都高于DM组（P〈0.01），相关分析表明IR与P-选择素呈正相关，多元回归显示DN发生与高FPG、高胰岛素、IR及P-选择素相关。结论P-选择素参与了IR，且P-选择素与IR一起参与了他T2DM患者DN的发生、发展过程。

Effect of P-selectin and insulin resistance on diabetic Nephropathy

Objective To study the association between P-selectin,insulin resistance（IR） and diabetic nephropathy（DN）. Methods Fresh plasma glucose（FPG）、insulin and P-seleetin were detected in 109 cases with type 2 diabetes mellitus（T2DM） ,which were seperated into groups ： Group DN, with nephropathy ; group DM, without nephropathy and normal control, then calculate the value of HOMA-IR. Results FPG、insulin、P-selectin and HOMA-IR in group DN and DM were remarkably higher than that in normal controls（ P 〈0.01 ） ,and the results above in Group DN were higher than that in Group DM （ P 〈0.01 ）. Related analysis showed that IR had positive correlation with P-selectin, multiple linear regression displayed that DN genesis had association with high FPG, hyper insulin, IR and P-selectin. Conclusion P-selectin has participate IR and together with IR participate the course of DN＇s genesis and development in T2DM.