小檗碱对清醒大鼠血液动力学的影响

静脉注射小檗碱(berberine,Ber)能引起清醒大鼠血压、左室压、及左室舒张末期压的降低。其下降程度DAp>SAP>LVSP心率先反射性加快后缓慢而持久下降。在后负荷及心率下降的同时并不伴有±(dp/dt)max,(dp/dt)p^-1的降低或LVP(dp/dt)p^-1环及其斜率的缩小,甚至还略有增加。这表明Ber对心肌的收缩性能有增强作用。因此降压效应主要为降低心率及外周血管阻力所致。

HEMODYNAMIC EFFECTS OF BERBERINL ON CONSCIOUS RATS

Berberine(Ber) (1mg/kg×3 or 10 mg/kg) given intravenously to conscious rats was shown to decrease BP, LVSP and LVEDP. The magnitude of decrease was in the order of DAP>SAP>LVSP. The HR was first accelerated reflexly and then decreased gradually and persistently. The cardiac contractility as shown by+(dp/dt)max,(dp/dt) p^-1 and LVP-(dp/dt)/P^-1 loop were not diminished and even augumented, in spite of the concomitant decrease of after load and heart rate. The above results indicate that Ber has positive inotropic and negative chronotropic actions on the heart, while its hypotensive effect is mainly due to lowering of total peripheral resistance in addition to slowing of heart rate.