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Brain-derived neurotrophic factor expression after long-term potentiation |
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| Authors: | Michael Dragunow Erica Beilharz Betty Mason Patricia Lawlor Wickliffe Abraham Peter Gluckman |
| Affiliation: | a Department of Pharmacology, University of Auckland Medical School, Auckland, New Zealand b Department of Pediatrics, University of Auckland Medical School, Auckland, New Zealand c Department of Psychology, Otago University, Dunedin, New Zealand |
| Abstract: | Long-term potentiation (LTP) of perforant-path dentate granule cell synapses, in awake rats, was followed by a time-dependent expression of brain-derived neurotrophic factor (BDNF) mRNA in dentate granule cells. This BDNF expression was blocked by the (NMDA) antagonist dizocilpine maleate (MK-801), which also blocked LTP induction, and by sodium pentobarbital, which shortens LTP persistence. These results suggest that BDNF may participate in the NMDA-receptor mediated cascade of events that result in LTP stabilization. |
| Keywords: | LTP Growth factor Memory Hippocampus BDNF Retrograde messenger |
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