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Hepatic Hemodynamic Changes Following Stepwise Liver Resection
Authors:Mohammad Golriz  Saroa El Sakka  Ali Majlesara  Arman Edalatpour  Mohammadreza Hafezi  Nahid Rezaei  Camelia Garoussi  Jalal Arwin  Arash Saffari  Hanna Raisi  Arezou Abbasi  Arianeb Mehrabi
Affiliation:1.Department of General, Visceral and Transplantation Surgery,University of Heidelberg,Heidelberg,Germany
Abstract:

Aim

Extended liver resection has increased during the last decades. However, hepatic hemodynamic changes after resection and the consequent complications like post hepatectomy liver failure are still a challenging issue. The aim of this study was to systematically evaluate the role of stepwise liver resection on hepatic hemodynamic changes.

Methods

To evaluate this effect we performed 25, 50, and 75 % sequential liver resections in 10 pigs. Before and after each resection, the hepatic artery flow and portal vein flow in relation to the remnant liver volume (RLV) as well as hepatic vascular pressures were measured and compared between the groups.

Results

Following sequential liver resection, the hepatic artery flow /100 g decreases and the portal vein flow increases up to 17 and 167 % following extended liver resection (75 %), respectively. Also, during stepwise liver resection, the portal vein pressure increases gradually up to 33 % following extended hepatectomy (75 %).

Conclusion

Sequential decrease in the RLV decreases the hepatic artery flow /100 g and increases the portal vein flow /100 g and portal vein pressure. As the consequence, the liver goes under more poor-oxygenated blood supply and higher pressure. This may be one of the most important mechanisms of the post hepatectomy liver failure in case of extended liver resection.
Keywords:
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