Stereospecificity of allergic contact dermatitis (ACD) to enantiomers |
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| Authors: | J. -L. Stampf C. Benezra Y. Asakawa |
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| Affiliation: | (1) Laboratoire de Dermato-Chimie, Associé au CNRS (LA 31), Université Louis Pasteur Clinique Dermatologique, CHU de Strasbourg, F-67091 Strasbourg, France;(2) Institute of Pharmacognosy, Tokushima Bunri University, Yamashiro-cho, 770 Tokushima, Japan |
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| Abstract: | Summary Guinea pigs were sensitized to polygodial 1, a natural sesquiterpene dialdehyde, using intradermal injections in Freund's complete adjuvant.Cross-reactions with a (±)-mixture of warburganal and (-)-warburganal 2 (a natural hydroxylated derivative of polygodial) showed a high specificity of the allergic response since the (-)-pseudoenantiomer (having the same configuration as the primary sensitizer) gave a stronger skin reaction than the racemic mixture. |
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| Keywords: | Polygodial Warburganal Allergic cross-reaction to pseudoenantiomers Delayed hypersensitivity |
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