道诺霉素和去炎松对实验性眼内细胞增生的抑制

以往的实验证实增殖性玻璃体视网膜病变（PVR）炎症期给以道诺霉素效果有限。我们在巨噬细胞注入兔玻璃体后6天再注入道诺霉素5μg,采用³H-胸腺嘧啶放射自显影观察了眼内细胞增生素，并与去炎松和两药联合的作用进行了比较。在28天时，道诺霉素组、去炎松组、联合用药组及对照组视网膜脱离率分别为33.3%、16.1%、8.3%和83.3%（P＜0.01）。放射自显影观察，道诺霉素使1、2周的标记细胞数明显减少（与对照组比分别为18.8±3.2对35.7±3.4;52.1±8.0对81.3±14.6，P＜0.01）；而去炎松及联合用药使炎细胞和标记细胞都明显减少。由此证实在PVR炎症期应用去炎松、细胞增生期应用道诺霉素或联合用药可防治牵拉性视网膜脱离。 （中华眼底病杂志，1994，10：229-231）

INHIBITION OF EXPERIMENTAL INTRAOCULAR CELULAR PROLIFERATION BY DAUNOMYCIN AND TRIAMCINOLONE

Our previous experiments showed limited results of treatment with daunomycin when given at the inflammatory stage of proliferative vitreoretinopathy(PVR)induced by macrophages in rabbits.In the present study,we observed the inhibition of intraocular cellular proliferation in the same model by daunomycin which was injected in a dosage of 5μg 6 days after intravitreal macrophage injection,with ³H-thymidine autoradiography.The efficacy of daunomycin was also compared with that of triamcinolone,and combined triamcinlone and daunomycin.The retinal detachment occurred in 33.3%,16.1%,8.3%and 83.3%(P＜0.01) of the eyes treated with daunomycin,triamcinolone,combined drugs and the control groups,respectively.Autoradiography revealed a singnificantly decreased number of labelled nuclei of proliferative cells on days 7 and 14 in daunomycin-treated eyes(compared to controls,18.8±3.2 vs 35.7±3.4;52.1±8.0 vs 81.3±14.6，P＜0.01,respectively).Significantly decreased numbers of inflammatory cells and labelled cells were also noted in eyes treated with triamcinolone and combined drugs.The results suggest that daunomycin given at the proliferative stage,and triamcionlone given at the inflammatory stage of PVR,or combined drugs can prevent traction retinal detachment. （Chin J Ocul Fundus Dis,1994,10:229-231）