Nitrofurantoin is active against vancomycin-resistant enterococci |
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| Authors: | Zhanel G G Hoban D J Karlowsky J A |
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| Institution: | Departments of Clinical Microbiology and Medicine, Health Sciences Centre and Faculties of Medicine and Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada. ggzhanel@pcs.mb.ca |
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| Abstract: | The activity of nitrofurantoin was tested against 300 isolates of Enterococcus faecium, Enterococcus faecalis, and Enterococcus gallinarum. No isolates tested were resistant to nitrofurantoin (MIC, >/=128 microg/ml), including vancomycin-resistant E. faecium isolates with vanA- and vanB-positive genotypes and vancomycin-resistant E. gallinarum isolates. We conclude that nitrofurantoin may provide effective treatment of urinary tract infections caused by vancomycin-resistant enterococci. |
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