Punicalagin promotes human villous trophoblast differentiation |
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| Affiliation: | 1. Department of Obstetrics and Gynecology, Washington University School of Medicine, 4566 Scott Ave., St. Louis, MO, 63110, USA;2. Department of Obstetrics and Gynecology, University of Campinas, Campinas, Brazil;1. Department of Otolaryngology, Medical University of Warsaw, Banach 1a, 02-097, Warsaw, Poland;2. Department of General and Experimental Pathology, Medical University of Białystok, Mickiewicza 2c, 15-222, Białystok, Poland;3. Department of Pediatric Otolaryngology, Medical University of Białystok, Waszyngtona 17, 15-274, Białystok, Poland;1. Maternal and Fetal Health Research Centre, University of Manchester, Manchester Academic Health Sciences Centre, Manchester M13 9WL, UK;2. Maternal and Fetal Health Research Centre, St Mary''s Hospital, Central Manchester University Hospitals NHS Foundation Trust, UK;3. Centre for Imaging Sciences, Institute of Population Health, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, UK;4. Gravida, University of Auckland, Auckland, New Zealand;1. Faculty of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China;2. Department of Food Science and Engineering, Department of Developmental and Regenerative Biology, Biopharmaceutical R&D Center, Jinan University, Guangzhou 510632, China;1. São Leopoldo Mandic Dental School and Research Center, Rua José Rocha Junqueira 13, Bairro Swift, Campinas, CEP: 13045-755, São Paulo, Brazil;2. Institute of Science and Technology of São José dos Campos, UNESP—Universidade Estadual Paulista, Avenida Engenheiro Francisco José Longo, 777, Jardim São Dimas, São José dos Campos, CEP: 12245-000, São Paulo, Brazil;3. Faculty of Medical Science (FCM), University of Campinas (UNICAMP), Rua Tessália Vieira de Camargo, 126 — Cidade Universitária Zeferino Vaz, Campinas, CEP: 13083-887, São Paulo, Brazil |
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| Abstract: | Poor differentiation of trophoblasts is associated with placental dysfunction, predisposing women to multiple pregnancy disorders. Punicalagin, a prominent ellagitannin in pomegranate juice has been shown to exert anti-apoptosis and anti-oxidative effects in human trophoblasts. We hypothesized that punicalagin modulates trophoblast differentiation. We found that punicalagin-treated primary trophoblast showed reduced E-cadherin, higher Syncytin 1, more β−hCG, and increased GCM1, an upstream regulator of β−hCG. Punicalagin exposure of villous explants enhanced the number of cytotrophoblasts expressing the proliferation marker Ki67. We conclude that punicalagin enhances trophoblast differentiation and speculate that punicalagin might be used therapeutically in pregnancies at risk for placental dysfunction. |
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| Keywords: | Placenta Polyphenol Differentiation Pomegranate GCM1" },{" #name" :" keyword" ," $" :{" id" :" kwrd0035" }," $$" :[{" #name" :" text" ," _" :" glial cell missing-1 β−hCG" },{" #name" :" keyword" ," $" :{" id" :" kwrd0045" }," $$" :[{" #name" :" text" ," _" :" beta subunit of human chorionic gonadotropin |
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