Nasal fluid secretory immunoglobulin A levels in children with allergic rhinitis |
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| Institution: | 1. Department of Pediatric Allergy and Immunology, Bezmialem Vakif University Medical Faculty, Istanbul, Turkey;2. Department of Clinical Microbiology, Bezmialem Vakif University Medical Faculty, Istanbul, Turkey;1. Department of the Respiratory Medicine, M.Iashvili Central Children Hospital, Aeyty Medical School, Tbilisi, Georgia;2. M.Iashvili Central Children Hospital, Tbilisi State Medical University, Tbilisi, Georgia;3. Prochild ONLUS, Trieste, Italy;4. Unit of Epidemiology, Biostatistics and Public Health, Department of Cardiology, Thoracic and Vascular Sciences, University of Padova, Padova, Italy;5. Internal Medicine Unit, Gemona del Friuli Hospital, Udine, Italy;1. Department of Paediatric Otolaryngology, Evelina London Children''s Hospital, Guy''s and ST Thomas’ NHS Foundation Trust, Westminster Bridge Road, London SE1 7EH, United Kingdom;2. Department of Otolaryngology, Southampton Children''s Hospital, University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton SO16 6YD, United Kingdom;3. Paediatric Intensive Care Unit, Evelina London Children''s Hospital, Guy''s and ST Thomas’ NHS Foundation Trust, Westminster Bridge Road, London SE1 7EH, United Kingdom;4. Department of Cardiology and Cardiac Surgery, Evelina London Children''s Hospital, Guy''s and ST Thomas’ NHS Foundation Trust, Westminster Bridge Road, London SE1 7EH, United Kingdom;1. Institute for Maternal and Child Health, IRCCS “Burlo Garofolo”, Trieste, Italy;2. Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy;1. Department of Pediatric Allergy, Dr Behcet Uz Children''s Hospital, Izmir, Turkey;2. Department of Pediatric Allergy, Dokuz Eylul University Medical School, Izmir, Turkey;1. Division of Otolaryngology—Head and Neck Surgery, University of Alberta, Edmonton, Alberta, Canada;2. Departments of Pediatrics, University of Alberta, Edmonton, Alberta, Canada |
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| Abstract: | ObjectivesThere is growing knowledge about the immunoregulatory and possibly preventative roles of immunoglobulin A (IgA) in allergic diseases. This study aimed to investigate secretory immunoglobulin A (SIgA) levels in the nasal fluid of children who were either being treated for their allergic rhinitis (AR) with intranasal mometasone furoate or were not receiving treatment.MethodsThe study population contained 55 children with persistent AR. Group I included 27 newly diagnosed AR patients not taking any medication and group II included 28 patients treated with intranasal steroids for at least 6 months. 27 healthy control subjects were also enrolled in the study. Total symptom scores (TSS) were calculated for each patient. Nasal secretions were obtained using a new modified polyurethane sponge absorption method, and samples were analysed by ELISA.ResultsThe median value for nasal fluid SIgA level in each group was 127.2 μg/ml (interquartile range; 67.3–149.6) in group I, 133.9 μg/ml (102.1–177.8) in group II and 299.8 μg/ml (144.5–414.0) in the control group. Groups I and II both had statistically significant reductions in nasal fluid SIgA levels compared to the control group (p < 0.001). However, there was no statistically significant difference between groups I and II (p = 0.35). A statistically significant and negative correlation also existed between TSS and nasal fluid SIgA levels in both groups I and II (p = 0.006, rho = ?0.512 and p = 0.01, rho = ?0.481, respectively).ConclusionsSIgA levels in the nasal fluid are significantly reduced in children with AR independent of treatment and are negatively correlated with the TSS. |
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| Keywords: | Allergic rhinitis Treatment Children Secretory IgA Nasal fluid Polyurethane |
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