Understanding heterogeneity in grey matter research of adults with childhood maltreatment—A meta-analysis and review |
| |
Institution: | 1. Department of Clinical Neuroscience, Karolinska Institute, Psychiatry Building R5:00, Karolinska, University Hospital, Stockholm 171 76, Sweden;2. Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden;3. Department of Clinical Sciences/Psychiatry, Umeå University, Umeå, Sweden;4. Department of Women''s and Children''s Health, Karolinska Institute, Stockholm, Sweden;5. Département de Psychiatrie, Université de Montréal, Montreal, QC, Canada |
| |
Abstract: | Childhood trauma has been associated with long term effects on prefrontal-limbic grey matter. A literature search was conducted to identify structural magnetic resonance imaging studies of adults with a history of childhood trauma. We performed three meta-analyses. Hedges’ g effect sizes were calculated for each study providing hippocampal or amygdala volumes of trauma and non-trauma groups. Seed based differential mapping was utilised to synthesise whole brain voxel based morphometry (VBM) studies. A total of 38 articles (17 hippocampus, 13 amygdala, 19 whole brain VBM) were included in the meta-analyses. Trauma cohorts exhibited smaller hippocampus and amygdala volumes bilaterally. The most robust findings of the whole brain VBM meta-analysis were reduced grey matter in the right dorsolateral prefrontal cortex and right hippocampus amongst adults with a history of childhood trauma. Subgroup analyses and meta-regressions showed results were moderated by age, gender, the cohort’s psychiatric health and the study’s definition of childhood trauma. We provide evidence of abnormal grey matter in prefrontal-limbic brain regions of adults with a history of childhood maltreatment. |
| |
Keywords: | Childhood trauma Abuse Grey matter Hippocampus Amygdala Voxel based morphometry Psychiatric diagnosis |
本文献已被 ScienceDirect 等数据库收录! |
|