| Institution: | 1. Laboratory for Research on Biologically Compatible Compounds, Faculty of Dental Medicine, Rue Avicenne, 5019, Monastir, Tunisia;2. Faculty of Sciences of Bizerte, Carthage University, Tunisia;1. Institute of Food Science, Zhejiang University, Yuhangtang Road 388, 310058 Hangzhou, China;2. Molecular Phytopathology and Mycotoxin Research, Georg-August-University Göttingen, Grisebachstrasse 6, 37077 Göttingen, Germany;3. Department of Plant Biochemistry, Albrecht-von-Haller-Institute for Plant Sciences, Georg-August-University Göttingen, Justus-von-Liebig-Weg 11, 37077 Göttingen, Germany;1. Food and Nutrition Department, National Institute of Health Dr. Ricardo Jorge, Av. Padre Cruz, 1649-016 Lisboa, Portugal;2. IIFA, Universidade de Évora, Palácio do Vimioso, Largo Marquês de Marialva, Apartado 94, 7002-554 Évora, Portugal;3. Centre for Environmental and Marine Studies, CESAM, University of Aveiro, Aveiro, Portugal;4. Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Post Box 5003, NO-1430 Aas, Norway;1. Discipline of Medical Biochemistry, University of KwaZulu-Natal, Durban, South Africa;2. Department of Physiology, University of Pretoria, Pretoria, South Africa;1. College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi 712100, China;2. College of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, Gansu 730050, China;1. Jiangsu Key Laboratory for Food Safety & Nutrition Function Evaluation, Huaiyin Normal University, Huai''an, 223300, PR China;2. Jiangsu Collaborative Innovation Center of Regional Modern Agriculture & Environmental Protection, Huaiyin Normal University, Huai''an, 223300, PR China;3. College of Food Science & Engineering, Shandong Agricultural University, Tai''an, 271018, PR China |
| Abstract: | Patulin (PAT) is a secondary toxic metabolite produced principally by Penicillium expansum. This mycotoxin is known to be teratogenic, mutagenic, immunotoxic and neurotoxic, and it has been shown to cause damage in several organs in laboratory animals. This study focuses on the prevention of experimental murine PAT-induced nephrotoxicity and hepatotoxicity. We investigate the ability of a natural product, crocin (CRO), to counteract the toxic effects of PAT. Pre-treatment of mice with CRO prevented PAT-induced oxidative damage in both liver and kidney. CRO reduced lipid peroxidation, protein oxidation and restored redox status by regulating the endogenous antioxidant enzymatic system. These data corroborate and extend findings in PAT-induced nephrotoxicity and hepatotoxicity, and further suggest that preventive effect of CRO towards other forms of PAT toxicity, including neurotoxicity, may be warranted. |
