Placental development during early pregnancy: Effects of embryo origin on expression of chemokine ligand twelve (CXCL12) |
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| Affiliation: | 1. Livestock Research Centre (LRC), Southern Regional Station (SRS), ICAR-National Dairy Research Institute (NDRI), Adugodi, Bengaluru 560 030, Karnataka, India;2. LRC, SRS, ICAR-NDRI, Adugodi, Bengaluru, India;3. Division of Animal Physiology, ICAR-National Institute of Animal Nutrition and Physiology (NIANP), Adugodi, Bengaluru 560 030, Karnataka, India;4. Division of Animal Nutrition, ICAR-NIANP, Adugodi, Bengaluru, India;5. SRS, ICAR-NDRI, Adugodi, Bengaluru, India |
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| Abstract: | The aim was to localize chemokine ligand twelve (CXCL12) in sheep placental tissues during early gestation and after assisted reproductive technologies (ART). Uteri were collected from naturally (NAT) mated ewes and ewes receiving embryo transfer (ET), in vitro fertilization (IVF) or in vitro activation (IVA). CXCL12 was immunolocalized to endometrial stroma, glands, and trophoblast. Greater CXCL12 immunoreactivity was present in trophoblast on day 22 and 24 and in NAT ewes compared to IVF and IVA. Increased CXCL12 expression suggests CXCL12 promotes implantation and placentation. Decreased CXCL12 in IVF and IVA embryos, may compromise pregnancy establishment when utilizing ART methods. |
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| Keywords: | CXCL12 Implantation Placentation Assisted reproductive technologies |
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