Four complement factor H gene polymorphisms in association with AMD: A meta-analysis |
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| Affiliation: | 1. Department of Ophthalmology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637007, Sichuan Province, China;2. Department of Ophthalmology and Optometry, North Sichuan Medical College, Nanchong 637007, Sichuan Province, China;3. Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hunghom, Hong Kong, China;1. San Antonio Military Medical Center, San Antonio, Texas;2. Galectin Therapeutics, Norcross, Georgia;1. Laboratoire de Transplantation et d''Immunogénétique, Département d''Immunologie, Institut Pasteur d''Algérie, Alger 16000, Algeria;2. INSERM, UMRS 1160, Hôpital Saint Louis, Paris 75010, France;3. Service de Rhumatologie, Etablissement Hospitalier Spécialisé de Douera, Alger 16000, Algeria;4. Laboratoire Jean Dausset et LabEx Transplantex, Hôpital Saint Louis, Paris 75010, France;5. Université Paris Diderot, Sorbonne Paris-Cité, Paris 75013, France;1. Department of Ophthalmology, Hospital Juan Ramón Jiménez, Huelva, Spain;2. Department of Microbiology, Hospital Juan Ramón Jiménez, Huelva, Spain;3. Department of Ophthalmology, Clínica Piñero, Sevilla, Spain;4. Department of Ophthalmology, Hospital Costa de la Luz, Huelva, Spain;5. Department of Pathology, Hospital Juan Ramón Jiménez, Huelva, Spain;6. Departament of Molecular Biology, HGC Biomedical Research Diagnostic S.L, Huelva, Spain;7. Department of Environmental Biology and Public Health University of Huelva, Huelva, Spain;1. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA;1. Key Laboratory of Carbohydrate and Lipid Metabolism Research, College of Life Science and Technology, Dalian University, 10-Xuefu Avenue, Dalian Economical and Technological Development Zone, Dalian, Liaoning 116622, China;2. Department of Cell Chemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan;3. Biomedical Engineering Department, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3107, USA;1. Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, Napoli, Italy;2. CEINGE–Biotecnologie Avanzate, Napoli, Italy;3. IRCCS–Fondazione SDN, Napoli, Italy;4. Dipartimento di Medicina e Chirurgia, Catterdra di Ginecologia e Ostetricia, Università degli Studi di Salerno, Salerno, Italy;5. Dipartimento di Scienze Ostetriche e Ginecologiche, Università degli Studi di Napoli Federico II, Napoli, Italy;6. Dipartimento di Neuroscienze, Scienze Riproduttive e Odontostomatologiche, Università degli Studi di Napoli Federico II, Napoli, Italy;7. Dipartimento di Scienze e Tecnologie Ambientali Biologiche Farmaceutiche, Seconda Università degli Studi di Napoli, Caserta, Italy |
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| Abstract: | AimTo investigate the possible association between CFH gene polymorphisms −543G > A (rs1410996), A473A (rs2274700), −257C > T (rs3753394), IVS15 (rs1329428) and AMD risk.MethodsWe searched the published literature in the Medline and Scopus from inception to May 2015. A meta-analysis was performed by the programs RevMan 5.1 and Stata 12.0, and the Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated in fixed or random effect model based on heterogeneity test among studies.ResultsNineteen studies with a total of 10,676 subjects were included in the present meta-analysis. A statistical significant association was observed between AMD risk and CFH −543G > A polymorphism with OR of 1.77 (95% CI, 1.47–2.12), 2.24 (95% CI, 1.71–2.94), 0.49 (95% CI, 0.38–0.62) and 0.25 (95% CI, 0.18–0.37) in additive, dominant, recessive and codominant models, respectively. Similar results were obtained in polymorphisms A473A, −257C > T, IVS15. Furthermore, stratified analysis for ethnicity showed a significantly strong association between −543G > A, A473A polymorphisms and AMD risk.ConclusionThe present meta-analysis suggested that CFH −543G > A, A473A, −257C > T, and IVS15 polymorphisms might be moderately associated with AMD risk. This conclusion warrants confirmation by further studies. |
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| Keywords: | Complement factor H Polymorphism Macular degeneration Meta-analysis |
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