双氢青蒿素哌喹片治疗无并发症恶性疟的临床随机对照试验

目的 :探讨双氢青蒿素哌喹片在柬埔寨马德望省治疗无并发症恶性疟的有效性和安全性。方法 :无并发症恶性疟疾病人 5 0例 ,按随机数字表随机分成 2组 ,每组 2 5例 ,一组用双氢青蒿素哌喹片 ,一组用复方双氢青蒿素片 ,采用 2d内 4次给药 ,成人总量 8片的给药方案 ,观察治愈率、复燃率、平均原虫转阴时间、退热时间和不良反应。结果 :双氢青蒿素哌喹片组的原虫转阴时间为 (36±s 2 0 )h ,复方双氢青蒿素片组为 (36± 17)h ;退热时间双氢青蒿素哌喹片组为 (4 2± 2 5 )h ,复方双氢青蒿素片为(31± 2 1)h ;随访 2 8d ,双氢青蒿素哌喹片组治愈率为 10 0 % ,复方双氢青蒿素片组有 1例于d 2 1复燃 ,治愈率为 96 %。病人对两药均有较好的耐受性 ,个别病人在服药过程中出现恶心、腹痛等症状 ,均轻微而且是自限性的。结论 :双氢青蒿素复方具有高效、速效、低毒、病人顺应好等优点。

Randomized controlled trial of dihydroartemisinin piperaquine phosphate tablet in treatment of uncomplicated falciparum malaria

AIM: To explore the effect and safety of dihydroartemisinin piperaquine(DP) phosphate tablet in treatment of uncomplicated falciparum malaria in battambang of Combodia. METHODS: Fifty patients with uncomplicated falciparum lalaria were randomly divided into two groups: DP group( n=25) and compound dihydroartemisinin(CD) group(n=25). The adult patients were treated with DP or artecom with a total dosage of 8 tables, qid, for 2 d. The cured rate, recrudes cence rate, mean parasite clearance time, mean fever clearance time, and adverse reactions were observed. RESULTS: The mean parasite clearance time (PCT) was (36±20) h in DP group and (36±17) h in artecom group. The mean fever clearance time (FCT) was (42±25) h in DP group and (31±20) h in CD group. The cured rate for 28-d follow-up was 100% in DP group and 96% in CD group. The patients had good tolerance to both drugs. A few patents felt nausea and epigastric pain. CONCLUSION: Both dihydroartemisinin compounds—Artekin and Artecom have high, fast effect, low toxicity and good tolerance and compliance for patients with falciparum malaria, Artekin is recommended for uncomplicated falciparum malaria considering to the cost of the drug and its mild adverse reaction.