新唑类抗真菌药物研究进展

近年来,新研制出一些唑类抗真菌药物,包括口服的伏力康唑、泊沙康唑、雷夫康唑;外用的舍他康唑、硫康唑、噻康唑等。这些药物扩大了现有唑类药物的抗菌谱,提供了更好的抗真菌活性。这些新的唑类抗真菌药物,尤其是系统用药已经在初步的临床实践中显示出较好的应用前景。为此,主要综述了新唑类抗真菌药物的临床应用的最新进展。

Progress of Azole Antifungal Agents

In recent years, some new azole antifungal agents have been developed, including oral and topical preparations, such as voriconazole, ravuconazole and posaconazole for oral use as well as sertaconazole, sulconazole and tioconazole for topical use. These new azoles present a broader antifungal spectrum and a more effective antifungal activity. They also have shown a good prospect in the preliminary clinical practice, especially the systemic antifungal agents. This review summarizes the current advance in clinical use of new azoles.