初诊时伴嗜酸粒细胞增多的外周 T细胞淋巴瘤 15例

目的探讨伴嗜酸粒细胞( EOS)增多的外周 T细胞淋巴瘤( PTCL)的发病机制、临床特点及治疗措施。方法分析安徽医科大学附属巢湖医院 2018年 7月收治的 1例及国内外近 5年文献报道确诊的 14例伴 EOS增多的 PTCL病人的临床资料，探讨该病的发病机制、临床特点及治疗和预后。结果 15例病人中高龄者多见， Ann Arbor分期晚，结外有多处组织侵犯，大多数国际预后指数( IPI)评分位于中高危组。除 1例失访外，化疗组( n=12)总生存时间［ 10.00(6.50，32.13)个月］与对症治疗组(n=2)总生存时间(分别为 11.00个月， 14.00个月)相比，差异无统计学意义( P>0.05)；一线方案化疗组( n=10)总生存时间［10.00(7.50，26.37)个月］与二线方案化疗组( n=2)总生存时间(分别为 2.50个月， 50.00个月)相比，差异无统计学意义( P>

Peripheral T-cell lymphoma with eosinophilia at initial diagnosis: 15 cases report

Objective To explore the pathogenesis, clinical features and treatment of peripheral T cell lymphoma (PTCL) with eosinophilia (EOS).Methods The clinical data of 1 case admitted to Chaohu Hospital Affiliated to Anhui Medical University in July 2018and 14 cases of PTCL patients with increased EOS reported in literatures at home and abroad in recent 5 years were analyzed.Results Most of the 15 patients were elderly, with late Ann Arbor stage and multiple extranodal tissue invasion. Most of the international prognostic index (IPI) scores were in the medium-high risk group, and multiple extra-junction tissues or organs were invaded with late Ann Arbor stage and most in high-risk group of international prognosis index (IPI). Except for 1 lost case, there was no significant differencein OS between the chemotherapy group (n=12) [10.00 (6.50, 32.13)] months, and symptomatic treatment group (n=2) (11.00 months and