| Affiliation: | (1) College of Oriental Medicine, Kyung Hee University, Seoul, Republic of Korea;(2) College of Pharmacy, Wonkwang University, Iksan, Jeonbuk, Republic of Korea;(3) Division of Beauty Arts, Jeonbuk Science College, Jeonegeup, Jeonbuk, 580-712, Republic of Korea;(4) Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk, 570-749, Republic of Korea;(5) Department of Emergency, Wonkwang University School of Medicine, Iksan, Jeonbuk, 570-749, Republic of Korea;(6) Department of Pharmacology, College of Oriental Medicine, Kyung Hee University, 1 Hoegi-Dong, Dongdaemun-Gu, Seoul, 130-701, Republic of Korea |
| Abstract: | Xanthii Fructus (XF) is an herb widely used in medicine for the treatment of a variety of inflammatory pathologies. In this study, using mouse peritoneal macrophages, we have examined whether XF affects nitric oxide (NO), tumor necrosis factor (TNF)-α, and interleukin (IL)-12p40 production induced by interferon (IFN)-γ and lipopolysaccharide (LPS). XF inhibits IFN-γ and LPS-induced NO production in a dose dependent manner. The decrease in NO synthesis was reflected as a decreased amount of inducible NO synthase protein. Furthermore, we also found that XF inhibits pro-inflammatory cytokine TNF-α production. However, treatment of XF in peritoneal macrophages had no effect on IL-12p40 production. These findings suggest that XF may be used in controlling macrophages-mediated inflammatory diseases. |
