SUPPRESSION BY GAMMA-HYDROXYBUTYRIC ACID OF ETHANOL WITHDRAWAL SYNDROME IN RATS |
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| Authors: | FADDA, FABIO COLOMBO, GIANCARLO MOSCA, ENRICA GESSA, GIAN LUIGI |
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| Affiliation: | Institute of Physiology University of Cagliari Via Porcell 4, 09124, Cagliari, Italy
*Department of Neurosciences, University of Cagliari Via Porcell 4, 09124 Cagliari, Italy |
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| Abstract: | The ability of gamma-hydroxybutyric acid to suppress ethanolwithdrawal syndrome was tested in male rats rendered physicallydependent on ethanol by several intragastric administrationsof ethanol (915 g/kg daily for 7 days). Gamma-hydroxybutyrate(0.25, 0.50 and 1.00 g/kg i.p.), administered 8 hr after thelast ethanol dose, produced a dose-dependent inhibition of withdrawalsigns such as tremors and audiogenically-induced seizures; thehighest dose tested suppressed all ethanol withdrawal symptoms. |
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