充血性心力衰竭时低钠血症治疗的进展

低钠血症是充血性心力衰竭的严重表现,通过限制水摄入,补充钠盐和利尿等常规治疗效果不理想。精氨酸血管加压素受体拮抗剂,是一种排水利尿剂,能促进肾集合管自由水的排泄,同时能维持血循环中钠和其它电解质浓度,对充血性心力衰竭的治疗有效。精氨酸血管加压素受体拮抗剂与血管紧张素转换酶抑制剂联合应用,能进一步使血管扩张,减少容量超负荷和纠正低钠血症,改善心功能。

Current Treatments for Hyponatremia in Congestive Heart Failure

Hyponatremia is a serious manifestation in congestive heart failure.Current options such as fluid restriction,administration of hypertension saline solution,and diuretic therapy have limited therapeutic effect.Arginine vasopressin receptor antagonists act as a aquaresis diuretic,and can increase free-water excretion in the renal collecting ducts and maintain blood volume sodium and the other electrolyte concentrations.It offers a clinical advantage in the treatment of hyponatremia.Combination therapy with vasopressin antagonists and ACE inhibitors can be an effective approach to managing vasoconstriction,volume overload and hyponatremia,and can thus improve heart function.