Activity of Ceftaroline against Enterococcus faecium PBP5 |
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| Authors: | Xavier Henry Oliver Verlaine Ana Amoroso Jacques Coyette Jean-Marie Frère Bernard Joris |
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| Affiliation: | Bacterial Physiology and Genetics Unit, Center for Protein Engineering, Life Science Department, University of Liège, Liège, Belgium |
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| Abstract: | The opportunistic human pathogen Enterococcus faecium overproduces the low-affinity PBP5. In clinical strains, mutations in PBP5 further reduce its acylation rate by β-lactams. Previous studies have reported that ceftaroline had poor inhibitory activity against β-lactam-resistant E. faecium strains. In this study, we show that ceftaroline exhibits killing activity against our laboratory-derived ampicillin-resistant E. faecium mutant that overproduces a wild-type PBP5 and that ceftaroline inactivates PBP5 much faster than benzylpenicillin and faster than ceftobiprole. |
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