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Activity of Ceftaroline against Enterococcus faecium PBP5
Authors:Xavier Henry  Oliver Verlaine  Ana Amoroso  Jacques Coyette  Jean-Marie Frère  Bernard Joris
Institution:Bacterial Physiology and Genetics Unit, Center for Protein Engineering, Life Science Department, University of Liège, Liège, Belgium
Abstract:The opportunistic human pathogen Enterococcus faecium overproduces the low-affinity PBP5. In clinical strains, mutations in PBP5 further reduce its acylation rate by β-lactams. Previous studies have reported that ceftaroline had poor inhibitory activity against β-lactam-resistant E. faecium strains. In this study, we show that ceftaroline exhibits killing activity against our laboratory-derived ampicillin-resistant E. faecium mutant that overproduces a wild-type PBP5 and that ceftaroline inactivates PBP5 much faster than benzylpenicillin and faster than ceftobiprole.
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