Combination effect of intraoperative and postoperative intravenous tranexamic acid in hip hemiarthroplasty. A propensity score matched analysis |
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| Institution: | 1. Department of Pediatrics, Johns Hopkins University School of Medicine; 733 N Broadway, Baltimore, MD 21205, United States;2. Division of Pediatric Emergency Medicine, Johns Hopkins University School of Medicine; 733 N Broadway, Baltimore, MD 21205, United States;3. General Pediatric Surgery, Johns Hopkins University School of Medicine; 733 N Broadway, Baltimore, MD 21205, United States;1. Department of Orthopedic Surgery, the Third Hospital of Hebei Medical University, No.139 Ziqiang Road, Shijiazhuang 050051 China;2. Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Hebei Province Key Laboratory of Environment and Human Health, No.361 Zhongshan Road, Shijiazhuang 050017 China;2. Department of Orthopaedics, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan;1. Orthopaedic Surgery Department, Vall d''Hebron University Hospital; Universitat Autònoma de Barcelona (Departament de Cirurgia i Cències Morfològiques). Barcelona, Spain;2. Septic and Reconstructive Surgery Unit, Orthopaedic Surgery Department, Vall d''Hebron University Hospital, Barcelona, Spain;3. Musculoskeletal Tissue Engineering Group, Vall d''Hebron Research Institute, Barcelona, Spain;4. Orthopaedic Surgery Department, Hospital de Sant Joan Despi Moises Broggi, Barcelona, Spain;5. Department of Radiology, Vall d''Hebron University Hospital, Barcelona, Spain;6. Orthopaedic Surgery Department; Hospital Clínico Universitario Virgen de la Arrixaca, Universidad de Murcia, Murcia. Spain;7. Septic and Reconstructive Surgery Unit, Orthopaedic Surgery Department; Hospital Clínico Universitario Virgen de la Arrixaca, Universidad de Murcia, Murcia. Spain;1. Department of Geriatric Rehabilitation, Meir Medical Center, Kfar Saba, Israel;2. Research Authority, Meir Medical Center, Kfar Saba, Israel;3. Beit Rivka Geriatric Rehabilitation Center, Petach Tikva, Israel;4. Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel |
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| Abstract: | BackgroundTranexamic acid (TXA) has been proven to reduce perioperative blood loss and the incidence of allogeneic blood transfusion in total joint arthroplasty (TJA). However, there is limited literature on the use of TXA in patients undergoing hip hemiarthroplasty. Furthermore, combination effect of intraoperative and postoperative intravenous TXA has not been investigated extensively. The purpose of this study was to evaluate this combination effect on hip hemiarthroplasty by a propensity score matched analysis (PSMA).MethodsThis is a retrospective cohort study involving hip hemiarthroplasty for femoral neck fracture. All patients received 1g intraoperative intravenous TXA. One group also received 1g intravenous TXA 6h after surgery, while the other group did not. Perioperative blood loss, the incidence of allogeneic blood transfusion and venous thromboembolism (VTE) were collected and compared.Results209 patients who underwent unilateral hip hemiarthroplasty were included. PSMA resulted in 66 matched pairs in each group. There were no significant differences in perioperative blood loss on postoperative day (POD) # 1, 3, 5 (637.2 ± 285.9 versus 653.6 ± 305.5, 726.6 ± 274.2 versus 676.3 ± 313.2, 795.5 ± 291.2 versus 759.9 ± 328.4), the incidence of allogeneic blood transfusion (9.1% versus 12.1%) and VTE (1.5% versus 1.5%) between the two groups (P value> 05) for up to one year.ConclusionIntraoperative and postoperative intravenous TXA have no combination effect on reducing perioperative blood loss, the incidence of allogeneic blood transfusion and VTE in patients undergoing hip hemiarthroplasty. |
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