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Comparison of careHPV and Hybrid Capture 2 Assays for Detection of High-Risk Human Papillomavirus DNA in Cervical Samples from HIV-1-Infected African Women
Authors:Jean Ngou  Mahlape P. Magooa  Clare Gilham  Florencia Djigma  Marie-Noelle Didelot  Helen Kelly  Albert Yonli  Bernard Sawadogo  David A. Lewis  Sinead Delany-Moretlwe  Philippe Mayaud  Michel Segondy
Abstract:The careHPV and HC2 assays were compared for high-risk human papillomavirus (HR-HPV) DNA detection in cervical samples from 149 HIV-1-infected African women. The HR-HPV DNA detection rates were 37.6% and 34.9% for careHPV and HC2, respectively. Agreement between the two tests was 94.6% (95% confidence interval [CI], 89.7% to 97.7%) with a kappa value of 0.88 (95% CI, 0.81 to 0.96), indicating an excellent agreement. careHPV may be considered as suitable as HC2 for cervical cancer screening among HIV-infected African women.
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